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Making reliable negative predictions of human skin sensitisation using an in silico fragmentation approach. The design, princkples and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation. Bioorg Med Chem Lett. Epub Mar A versatile interactive high-resolution scientific multi-panel visualization toolkit.
Long-term treatment with atazanavir ATV enginedring real life in Belgium: First-in-human study to assess the safety, pharmacokinetics and pharmacodynamics of BMS, a direct, reversible, small molecule factor XIa inhibitor in non-Japanese enhineering Japanese healthy subjects.
Clin Appl Thromb Hemost. Epub Jan Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. Long-term follow-up of clinical trial patients treated for chronic HCV infection with daclatasvir-based regimens. Discontinuation risk comparison among ‘real-world’ newly anticoagulated atrial fibrillation patients: Apixaban, warfarin, dabigatran, or rivaroxaban.
Surface plasmon resonance as a tool for ligand-binding assay reagent characterization in bioanalysis of biotherapeutics. Gradient elution behavior of proteins in hydrophobic interaction chromatography with U-shaped retention factor curves.
The expanding role of prodrugs in contemporary drug design and development. A Quantitative Targeted Proteomics Study. Monitoring of multiple solvent induced form changes during high shear wet granulation and drying processes using online Raman spectroscopy. High-efficiency affinity precipitation of multiple industrial mAbs and Fc-fusion proteins from cell culture harvests using Z-ELP-E2 nanocages.
An Elemental Impurities Excipient Database: In silico toxicology protocols. Predictive probability methods for interim monitoring in clinical trials with longitudinal outcomes. Bioinspired supramolecular engineering of self-assembling immunofibers for high affinity binding of immunoglobulin G.
Contributions of depth filter components to protein adsorption in bioprocessing.
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A three-point identity criteria tool for establishing product identity using icIEF method. Epub Mar 1. Antibody dependent cellular phagocytosis by macrophages is a novel mechanism of action of elotuzumab. J Chem Theory Comput. Nivolumab with or without ipilimumab in patients with recurrent glioblastoma: Simultaneous determination of trace concentrations of aldehydes and carboxylic acids in particulate matter. Effective transposition of the P4 hydrogen bond donor. Critical role of method development in ensuring assay quality.
J Pharm Biomed Anal. Nivolumab versus docetaxel in previously treated advanced non-small-cell lung cancer CheckMate and CheckMate Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Epub Feb Hypoxia and transforming growth factor-beta1 pathway activation promote Chinese Hamster Ovary cell aggregation. Mechanism and potential mitigation strategies. Safety profile of nivolumab administered as min infusion: In-process rheometry as a PAT tool for hot melt extrusion.
Antithrombotic therapy use and clinical outcomes following thrombo-embolic events in patients with atrial fibrillation: Epub Jan 3. Flow, Particle Size, and Tooling Dimension. Lack of ethnic differences of moxifloxacin and metabolite pharmacokinetics in East Asian men.
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Epub Nov Economic burden of multiple myeloma among patients in successive lines of therapy in the United States. Improving titer while maintaining quality of final formulated drug substance via optimization of CHO cell culture conditions in low-iron chemically defined media. A natively paired antibody library yields drug leads with higher paal and specificity than a randomly paired antibody library.
Using hydrogen peroxide to prevent antibody disulfide bond reduction during manufacturing process. Monoclonal antibody higher order structure analysis by high throughput protein conformational array. Combining intratumoral Treg depletion with androgen deprivation therapy ADT: Prostate Cancer Prostatic Dis. Epub Dec 4. Potential impurities in drug substances: Compound-specific toxicology limits for 20 synthetic reagents and by-products, and a class-specific toxicology limit for alkyl bromides.
Association of anti-cyclic citrullinated protein antibodies, erosions, and rheumatoid factor with disease activity and work productivity: A patient registry study. Epub Oct Bioprocfss to seronegative status after abatacept treatment in patients with early and poor prognostic rheumatoid arthritis is associated with better radiographic outcomes and sustained biopgocess Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form.
Posttransplant reduction in preexisting donor-specific antibody levels after belatacept- versus cyclosporine-based immunosuppression: Ebgineering flow modulates electrical activity in cardiac hERG potassium channels. Results From the CA Study. Design Paradigm ;al Developmental Challenges.
Treatment Challenges in Venous Thromboembolism: An Appraisal of Rivaroxaban Studies. Retention and clinical response to abatacept in patients with rheumatoid arthritis: Determination of polymeric impurities in asunaprevir drug substance and product using size exclusion effect of reversed-phase columns.
Treatment patterns for patients hospitalized with chronic obstructive pulmonary disease. Interim results of brentuximab vedotin in combination with nivolumab in patients with relapsed or refractory Hodgkin lymphoma.
Industrial bioprocessing perspectives on managing therapeutic protein charge variant profiles. The cost-effectiveness of nivolumab monotherapy for diran treatment of advanced melanoma patients in England. Modeling the economic outcomes of immuno-oncology drugs: Analytical comparability study of recombinant monoclonal antibody therapeutics.
De novo donor-specific antibodies in belatacept-treated vs cyclosporine-treated kidney-transplant recipients: Strategy To Prepare enguneering and 3-Chloropyrazoles.
Comparative untargeted proteomic analysis of ADME proteins and tumor antigens for tumor cell lines.
Apixaban following acute coronary syndromes in patients with prior stroke: Discovery of morpholine-based aryl sulfonamides as Na v 1. Epub Feb 1. Prediction of olanzapine exposure in individual patients using physiologically based pharmacokinetic modelling and simulation. The Clinical Pharmacology of Elotuzumab.
Treatment and discharge patterns among patients hospitalized with non-valvular atrial fibrillation transitioning from the inpatient to outpatient setting. Comparison of major bleeding risk in patients with non-valvular atrial fibrillation receiving direct oral anticoagulants in the real-world setting: Outcomes associated with warfarin time in therapeutic range among US veterans with nonvalvular atrial fibrillation.
Enferm Infecc Microbiol Clin. Integrating new approaches to atrial fibrillation management: Risk Modification by Concomitant Antiretrovirals. Real-world comparison of all-cause hospitalizations, hospitalizations due to stroke and major bleeding, and costs for non-valvular atrial fibrillation patients prescribed oral anticoagulants in a US health plan. Comparative evaluation of treatment patterns and healthcare utilization of newly-diagnosed rheumatoid arthritis patients by anti-cyclic citrullinated peptide antibody status.
Immune Modulation Therapy and Imaging: Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: Neural correlates of audiovisual sensory integration. Evidence for a Nitrenoid in Catalytic Cadogan Cyclizations. Evaluation of comparative effectiveness research: Streamlining Adverse Events Reporting in Oncology: Epub Dec Genomic correlates of response to immune checkpoint therapies in clear cell renal cell carcinoma.
Development of a series of novel o-phenylenediamine-based indoleamine 2,3-dioxygenase 1 IDO1 inhibitors.